This site requires Javascript.

Please enable Javascript before proceeding:

Firefox

  1. In the FireFox address bar, type about:config.
  2. Look for the javascript.enabled setting.
  3. Set it to true by right-clicking and pressing toggle.

Internet Explorer

  1. On the Tools menu, click Internet Options, then click the Security tab.
  2. Click the Internet Zone.
  3. If you do not have to customize your Internet security settings, click Default Level. Then do step 4.
  4. If you have to customize your Internet security settings, follow these steps:
    a. Click Custom Level.
    b. In the Security Settings - Internet Zone dialog box, click Enable for Active Scripting in the Scripting section.
  5. Click the Back button to return to the previous page, and then click the Refresh button to run scripts.

Chrome

  1. In the Chrome address bar, type chrome://settings/content/javascript.
  2. Adjust the toggle so that javascript is allowed.
  3. Close the Settings tab and Refresh the page.

 

Program

Click here to download the detailed program.

Time Session Information - Wednesday April 24, 2019
12:00 - 13:00 Registration and Lunch
The Conceptual Challenges
13:00 - 13:20 The Challenge of PD as many Diseases - Clinical, Genetic, Pathologic, Environmental Variability
Anthony Lang, Toronto
Permission
Not
Granted
13:20 - 13:40 Challenges to Study Disease Modification in Non-Manifesting at Risk Subjects (gene carriers, “prodromal PD” using new MDS-Criteria)
Ron Postuma, Montreal
Permission
Not
Granted
13:40 - 14:00 Challenges in Neuropathology: Do “copathologies” represent modifiers of PD (Revision) or an invitation to reconsider PD nosology (Reconstruction)?
John Trojanowsi, Philadelphia

Download
14:00 – 14:20 The Challenge of Revision vs Reconstruction
Alberto Espay, Cincinnati

Download
14:20 – 14:50 Discussion
José Obeso, Madrid; Jon Stoessl, Vancouver
Not Applicable
14:50 – 15:15 Refreshment Break
EXPERIENCES IN OTHER DISEASES IN NEUROLOGY AND MEDICINE
15:15 – 15:35 Alzheimer's Disease - problems of retaining old constructs; examples of reasons for and successes in revising concepts of disease subtyping
George Perry, San Antonio

Download
15:35 – 15:55 Impact of Breast Cancer Molecular Subtypes on Clinical Decision-Making
Philippe Bedard, Toronto

Download
15:55 – 16:15 The Transformation of Cystic Fibrosis: Molecular therapies for a diverse range of genetic causes
Steven Rowe, Birmingham

Download
16:15 – 16:45 Discussion
Alberto Espay, Cincinnati; Francesca Morgante, London UK
Not Applicable
Time Session Information - Thursday April 25, 2019
7:00 - 8:00 Registration and Continental Breakfast
Disease Mechanisms
8:00 - 8:30 Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression
Virginia Lee, Philadelphia

Download
8:30 - 8:50 Mechanistic Insights into GBA1-Associated Parkinson’s Disease and Development of Targeted Therapies
Dmitri Krainc, Chicago

Download
8:50 - 9:10 A Genetic Basis for Synaptic-Endosomal Dysfunction in Parkinson’s Disease
Matt Farrer, Vancouver

Download
9:10 - 9:40 Discussion
Adriano Aguzzi, Zürich; Antonio Strafella, Toronto

Not
Applicable

9:40 - 10:10 Break
10:10 - 10:30 LRRK2 as a Therapeutic Target for Parkinson’s Disease – Revise or Reconstruct
Lorraine Kalia, Toronto

Download
10:30 - 10:50 Bioenergetic Determinants of Neuronal Vulnerability in Parkinson’s Disease
James Surmeier, Chicago
Permission
Not
Granted
10:50 - 11:10 Neuroinflammation and Role of the Microbiome in Parkinson Disease
David Standaert, Birmingham

Download
11:10 - 12:10 Discussion
Patrik Brundin, Grand Rapids; Andy Singleton, Bethesda
Not
Applicable
12:10 - 13:10 Lunch
TRANSPLANTATION & OTHER STRATEGIES directed primarily at augmenting dopamine function (Neurorescue/Neurorestoration-based treatments)
13:10 - 13:30 YES - Nigrostriatal dopamine will remain a primary target and reinnervation should be pursued
Roger Barker, Cambridge

Download
13:30 - 13:50 NO - Nigrostriatal dopamine will not remain a primary target and reinnervation should not be pursued.
Jeffrey Kordower, Chicago

Download
13:50 - 14:30 Rebuttal and Discussion
Andres Lozano, Alfonso Fasano, Toronto
Permission
Not
Granted
14:30 - 15:00 Break
BIG DATA, MACHINE LEARNING, NEW TECHNIQUES, VIRTUAL COHORTS
15:00 - 15:30 What do PD cohort studies tell us – one disease or many?
Caroline Williams-Gray, Cambridge

Download
15:30 - 16:00 Thermodynamically Inspired Biomarkers – Transferring Concepts from Physics and Ecology to Medicine
Rudi Balling, Luxembourg
Permission
Not
Granted
16:00 - 16:40 Discussion
Todd Sherer, New York; Ronan Fleming, Leiden

Not
Applicable

Time Session Information - Friday April 26, 2019
7:00 - 8:00 Registration and Continental Breakfast
Trials - Biomarkers, Trial designs, consortiums, etc. What can be pursued in the near future and how?
8:00 - 8:30 Fit-for-Purpose Applicationsn of Biomarkers in PD Drug Development
Jesse Cedarbaum, Boston
Permission
Not
Granted
8:30 - 9:00 Discussion
Ken Marek, New Haven
Not
Applicable
Trials - Trial designs including Lessons Learned
9:00 - 9:30 Lessons from Anti-Amyloid-β Immunotherapies in AD
Howard Chertkow, Toronto
Permission
Not
Granted
9:30 - 10:00 Role of Novel End-Points and Evaluations of Response
Michael Schwarzschild, Boston
Permission
Not
Granted
10:00 - 10:20 Break
10:20 - 10:50 Novel trial designs of “disease modifying therapy” in oncology (e.g., I-SPY2) and other diseases
Christopher Coffey, Iowa City
Permission
Not
Granted
10:50 - 11:20 Time for a New Framework for ‘Disease Modifying’ Clinical Trials in Parkinson’s Disease
Karl Kieburtz, Rochester
Permission
Not
Granted
11:20 - 11:50 Regulatory Modifications that Could Facilitate Development of a Neuroprotective Therapy for PD 
Warren Olanow, New York
Permission
Not
Granted
11:50 - 12:35 Discussion
Hubert Fernandez, Cleveland; Karl Kieburtz, Rochester; Warren Olanow, New York
Not
Applicable
12:35 - 12:50 Concluding Summary/Remarks
Anthony Lang, Toronto

Register
Returning Registrant

Date

April 24 – April 26, 2019

Rates

Non-physician Rate
(e.g. scientists, fellows, residents)
$395
Physician Rate $495

Location

Marriott Downtown at
CF Toronto Eaton Centre
525 Bay Street
Toronto, ON  M5G 2L2

More Information

Conference Services
conference@uhn.ca
416-597-3422 ext 3448